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Definition of AIM-Ready Projects

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This page serves as guidance to help Stanford PIs receive clarity on whether their projects may be of interest to the Stanford AIM Review Committee.

Project Scenarios of Interest

  • Novel target/mechanism/phenotype linked to a disease with high unmet medical need and a confirmed hit (any modality utilizing Takeda capability areas)
  • Novel target/mechanism/phenotype linked to a disease with high unmet medical need with no confirmed hits, but with either a robust primary assay ready for HTS optimization, unique expertise from the PI lab for the development of assays or an alternative approach to identifying progress-able hits such as structural modelling and virtual screening approaches
  • Novel¬†chemical biology or biological (therapeutic proteins, gene therapy, antisense and editing, oligonucleotides, cell therapy, oncolytic viruses)¬†approach to an existing target where unmet medical need remains
    • Examples include, but are not limited to (a) allosteric modulators where previous unsuccessful work described orthosteric modulators; (b) irreversible covalent modulators with increased affinity where previous unsuccessful work described reversible non-covalent weak binders; (c) PROTAC degraders for difficult to drug protein-protein interactions (d) Protein, antibody, cellular and genetic approaches to disease modulation
  • Novel combinations, e.g. optimization of the PK of one drug via new chemistry to make it more compatible with its partner drug

Project Scenarios Not Part of AIM Mandate

  • Medical device
  • Diagnostic without associated therapeutic
  • Biomarker without associated therapeutic
  • Use of known non-proprietary tool to identify target/MOA with disease
  • Novel target/phenotype linked to a disease area already well-served by approved medications
  • Reformulations of drugs